I love all of these lined bags from Alchemy (I bought one of every size when they were on sale) but the big one I carry with me everywhere with my medications (with devices I pack almost 2 pounds in this thing) and I LOVE IT!!
I stuff this thing full and toss it in my car seat, my backpack, my winter coat pocket (the big ones), and all over the house. It is rugged and seems to protect really well the contents inside, as nothing of mine has been damaged while inside .
The dimensions seem to meet in that sweet section of the Venn diagram made of the circles "size economy" and "storage capacity" in my experience. In other words, a perfect meeting of form and function in this thing!!
The inner nylon is strong and while not advertised as heat proof, I have placed hot items on the outer rubber and very, very warm items inside on the nylon fabric and neither have shown a mark.
It is not smell proof, but it's dimensions allow for MULTIPLE smell proof containers for those more noxious medications (fish oil, etc), in fact, welcomes them into the nylon interior with warm arms, along with space for your medications' device(s).
Really, though, it happens to fit my needs perfectly, and for that, I am sooooo happy and grateful. Definitely getting some more as gifts for friends who have complimented mine. This bag is so banging, I won't even wait for the sale price!